Question Is gait speed measured at age 45 years associated with accelerated biological aging, neurocognitive function, and cognitive decline? Findings In this 5-decade cohort study of 904 participants in New Zealand, physical and biological indicators of accelerated aging, including compromised brain integrity (eg, reduced brain volume and cortical thickness), were associated with slow gait measured at age 45 years. Lifelong compromised brain health—including poor neurocognitive functioning as early as age 3 years and childhood-to-adulthood decline in cognitive functioning—was associated with slower gait at midlife. Meaning Gait speed at midlife may be a summary index of lifelong aging with possible origins in childhood central nervous system deficits. Read more here. (JAMA Network) Basically, the slower you walk as you get to age 45, the more likelihood you will have some indicators of accelerated aging.