Health Biomarkers in fathers’ sperm linked to offspring autism

tom_mai78101

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PULLMAN, Wash. – Biomarkers in human sperm have been identified that can indicate a propensity to father children with autism spectrum disorder. These biomarkers are epigenetic, meaning they involve changes to molecular factors that regulate genome activity such as gene expression independent of DNA sequence, and can be passed down to future generations.

In a study published in the journal Clinical Epigenetics on Jan. 7, researchers identified a set of genomic features, called DNA methylation regions, in sperm samples from men who were known to have autistic children. Then in a set of blind tests, the researchers were able to use the presence of these features to determine whether other men had fathered autistic children with 90% accuracy.

“We can now potentially use this to assess whether a man is going to pass autism on to his children,” said Michael Skinner, professor of biological sciences at Washington State University and corresponding author on the study. “It is also a major step toward identifying what factors might promote autism.”

Incidence of autism spectrum disorder has increased dramatically over time from 1 in 5,000 people in 1975 to 1 in 68 in 2014. While improved diagnosis and awareness can account for some of that change, many researchers believe the recent increase over the last two decades may be due to environmental and molecular factors. Previous studies have also shown that children can inherit the disorder from their parents, and that fathers are more often linked to autism transmission than mothers.

In the current study, researchers from WSU, Valencia Clinical Research Center and Valencia University in Spain, looked at sperm epigenetics, the molecular processes that affect gene expression, in two groups of men: 13 who had fathered sons with autism, and 13 who had children without the disorder. They looked specifically at DNA methylation, a chemical modification that happens when a methyl group attaches to a DNA strand and can turn genes on or off.

Read more here. (Washington State University)
 
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    The Texas power got deregulated and they messed it up real good they absolutely did nothing to try and protect the grid from weather
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    basically they took away all the safeguards to save money and then the worst happened lol
  • The Helper The Helper:
    they did not winterize any of the plants and they froze
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    it is not that power consumption went up it was available capacity went down with power plants freezing
  • Varine Varine:
    What a fucking disaster. Are all of the Texas people okay? I see TH is, are we the only two?
  • Varine Varine:
    How have the other states held up? I just got power back so I have no idea what's going on, we didn't get warning
  • Varine Varine:
    Why the fuck didn't they fix this ten years ago when it happened?
  • Blackveiled Blackveiled:
    I'm in it with you and TH as well. My power has been in and out, and I have a ruptured pipe that I need to fix, shouldn't be too bad to fix myself.
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    I hope you're staying warm! Apparently the supply is coming up so hopefully we can get back to normal power soon, mine has been on for six hours now.
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    My power has been off most of the last 2 days. We had a generator installed 3 years ago though, so we're staying warm. Water is another issue...
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    Where I live has a pool so we are using that to get water to flush the toilets. We have enough bottled water to drink and brush teeth and stuff but it has been a few days and no shower though....
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    I had some water in gallon jugs, and got our water back on yesterday. We don't seem to have any leaks, but I haven't crawled down there to look yet.
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    still no water I cannot remember when I last showered now I know how they felt in the old west lol
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    My poor plants are happy, they aren
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    aren't used to going this long without water or lights or normal heat. I think a couple of them froze, but they look like they'll make it
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    Well one of them is pretty rough but I think it was sick to begin with, that one always had some problems.
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    ???
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    That is such a Texas thing to say lol
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    a positive could come out of this. So many people trapped at home could put a dent in the covid numbers in Texas
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    That dude, Tom Boyd, is really upset about the backlash from his "it's your fault you're freezing" thing because he claims he resigned before saying it, so it wasn't like he said it in his official capacity or anything.
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    Almost as if he was saying "screw you guys, I'm going home"
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    I'm fairly new here still but that seems to be the analogous message by several of our politicians.
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    Nobody?
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    Hi vypur85, long time no see

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