Sci/Tech Israel: Tiny hybrid robot can identify, capture a single cell

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Researchers from Tel Aviv University, Israel, have created a micro-robot the size of a single biological cell that navigates using both electricity and magnetic fields and can identify and capture a single cell, opening the door to a vast array of applications.

Inspired by biological “swimmers” such as bacteria and sperm, the researchers developed a micro-robot (about 10 microns across) with the ability to move around the body autonomously or controlled by an operator.

Using a magnetic field to propel the micro-robot, also called a micro-motor, was attractive; it doesn’t require fuel or direct contact between the magnet and body tissues, can be steered accurately, and can function in a wide range of temperatures and solution conductivities. Electrically powered micro-motors offer advantages, such as selective cargo loading, transport and release and the ability to use electricity to “deform” cells, but they have some downsides. So, combining the two was a no-brainer.

“The micro-robots that have operated until now based on an electrical guiding mechanism were not effective in certain environments characterized by relatively high electrical conductivity, such as a physiological environment, where the electric drive is less effective,” said Gilad Yossifon, corresponding author of the study. “This is where the complementary magnetic mechanism comes into play, which is very effective regardless of the electrical conductivity of the environment.”

Once the hybrid propulsion system was assembled, researchers were able to demonstrate the micro-robot’s capabilities. They used it to capture a single red blood cell, cancer cells, and a single bacterium, demonstrating that the micro-robot could distinguish between a healthy cell and one that had been damaged by a drug or a dying cell and one that was undergoing a natural “suicide” process (apoptosis). Once captured, the cell can be moved to an external instrument for further analysis.

 
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