Report Little-known psychedelic found to have a fascinating effect on cognitive flexibility after just a single dose

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A new study published in Molecular Psychiatry has revealed that a single dose of the psychedelic drug 2,5-dimethoxy-4-iodoamphetamine (DOI) can lead to long-lasting changes in brain structure and cognitive flexibility in mice. The researchers found that mice treated with DOI became more attuned to previously overlooked cues, allowing them to learn more efficiently from their experiences. These effects appeared to depend on the timing of drug administration and the animals’ experiences after the treatment.

DOI is a synthetic psychedelic from the amphetamine class that acts primarily by activating serotonin receptors in the brain. It is known for inducing long-lasting alterations in perception and has been studied for its ability to promote neuroplasticity, or the brain’s ability to form new connections. But much of this work has focused on the short-term effects immediately following drug administration.

Less is known about how these structural changes in the brain translate into long-term behavioral adaptations, particularly in relation to cognitive flexibility, a key feature of mental health and well-being. Cognitive flexibility is the ability to adapt one’s thinking or behavior in response to new information or changing circumstances, and impairments in this ability are often linked to mental health disorders such as depression, anxiety, and obsessive-compulsive disorder.

“My research interests are about cognitive flexibility in general and its relationship to brain plasticity changes. Many neuropsychiatric conditions share a common symptom of cognitive rigidity, so I wanted to study how enhancing neuroplasticity could unlock a more flexible cognitive state to get a stuck brain unstuck. When I was writing my PhD proposal, the psychedelic hype was just starting to pick up and what attracted me was the idea that I can use these drugs as a tool to induce rapid and enduring neuroplasticity,” explained Merima Šabanović, a postdoctoral associate at the Department of Psychiatry at Weill Cornell Medicine.

 
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    But the electorate would have to demand it and vote people in to do it.
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    Government spending, foreign policy, and the southern border are all bigger issues than the income tax right now I'd say.
  • The Helper The Helper:
    For you those are the bigger issues. Cannabis legalization and get rid of Income tax are mine.
  • Ghan Ghan:
    We have so much cannabis up here in Oklahoma. Can't go a block without running into 3 dispensaries. xD
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    if the demand is there
  • jonas jonas:
    I think the biggest issue in USA is how divided the country has become
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    There's a big split happening in fundamental values that is very worrisome.
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    I think there's always been a split in values. But now there's a split in what reality is. No matter whom you ask, they think a third of the country is insane and wants to destroy the country
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    pretty big split
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    Happy Saturday!
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  • Varine Varine:
    I just don't think Trump actually understands how the government works. I'm not going to pretend like I can understand the entirety of government but in my industry he kind of caused massive fucking issues. Tarriffs and the international counters had a pretty significant impact on what I do, it was actually kind of interesting to see though. I live in Idaho so I'm not really concerned with it, it'll be R pretty much the entire way down. We do have ranked choice on our ballot this year though and I DO really care about that. But if we are going to have a federal government we kind of need income tax. They could abolish it and tax states I guess, but then states are just going to raise income taxes. It's not really viable without a very significant and holistic overhaul of how the federal government works, and that isn't something I would expect Trump to do.
  • Varine Varine:
    I don't expect Harris to do it either. I want to see wealth and church taxes, but those also aren't things I'm going to hold my breath for.
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    I mean he definitely doesn't, which is why he had to retract most of his executive orders, didn't manage to get rid of obamacare etc.
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  • jonas jonas:
    Replacing income tax with a wealth tax would be amazing imho, but I can't even imagine that this would happend
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    Wealth tax would be a disaster. Imagine having to liquidate retirement accounts because you have a tax bill just for unrealized gains. Or your house goes up in price and you have to sell it to pay the tax bill.
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    I'm not talking about an income tax on wealth gain.
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    we already have a wealth tax on our house, it's called a property tax. I'm talking about extending that to other income-generating assets like private equity, bonds and stocks.
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    I agree that the effect of that would be to depress asset prices, but I think that's a good thing. Makes it easier for hard working young people to grow their retirement income
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  • seph ir oth seph ir oth:
    Potential problem for a wealth tax for the US would be the ultra rich just offshoring assets in another country without a wealth tax. Those that would eat the wealth tax on, say, stocks, would be the middle class that puts money slowly into the market via the likes of funds.
  • seph ir oth seph ir oth:
    happy US election day btw!
  • Varine Varine:
    Oh election day

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