Science Researchers find CRISPR-Cas9 gene editing approach can alter the social behavior of animals

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Georgia State University scientists have created gene-edited hamsters for studies of social neuroscience and have found that the biology behind social behavior may be more complex than previously thought.

A team of Georgia State University researchers led by Regents' Professor of Neuroscience H. Elliott Albers and Distinguished University Professor Kim Huhman used CRISPR-Cas9 technology to eliminate the actions of a neurochemical signaling pathway that plays a critical role in regulating social behaviors in mammals. Vasopressin and the receptor that it acts on called Avpr1a regulates social phenomena ranging from pair bonding, cooperation, and social communication to dominance and aggression. The new study, published in the Proceedings of the National Academy of Sciences (PNAS), finds that knocking out the Avpr1a receptor in hamsters, and thus effectively eliminating vasopressin's action on it, dramatically altered the expression of social behavior in unexpected ways.

"We were really surprised at the results," Albers said. "We anticipated that if we eliminated vasopressin activity, we would reduce both aggression and social communication. But the opposite happened."

Instead, the hamsters without the receptor showed much higher levels of social communication behavior than did their counterparts with intact receptors. Even more interesting, the typical sex differences observed in aggressiveness were eliminated with both male and female hamsters displaying high levels of aggression towards other same-sex individuals.

 
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  • tom_mai78101 tom_mai78101:
    Hmm, about the Headline News, I noticed threads are being moved into the subforum (Health News, Environmental News, etc.). When that happens, the TH Forum Home page loses the articles, and instead would show old articles posted 1 or 2 weeks ago.
  • tom_mai78101 tom_mai78101:
    What do we do with the Home page?
  • Ghan Ghan:
    I added those forums to the filter for that widget.
    +1
  • tom_mai78101 tom_mai78101:
    Oh nice. They're back. Thanks.
  • tom_mai78101 tom_mai78101:
    Now I think it makes more sense for me to put news in their own subforums, without worry.
  • The Helper The Helper:
    Awesome Ghan thanks! I was purposely not moving the first 15 news articles in Headline news to the different subforums but I guess I don't have to do that now?
  • tom_mai78101 tom_mai78101:
    Question: Is there a way to remove thread redirects? It creates a copy of the moved thread and takes up space, and I am leaning towards wanting to remove them in the Headline News. But if they have an expiration date, I guess I'm fine with it.
  • The Helper The Helper:
    If you move a thread please leave a permanent redirect. You can delete any redirects after 6 months. The redirects are left to help Search Engines find the moved content.
  • tom_mai78101 tom_mai78101:
    What if you move the permanent redirect, not the thread?
  • The Helper The Helper:
    I think that works but I have not messed with it. You can delete redirects though if you have to that will not delete the original thread
  • The Helper The Helper:
    if a redirect ends up in the same forum as the post it goes to though I think the redirect drops or fails or something but they are not bugged out and when you are working on an indirect the original post is safe.
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    Happy Early Friday :)
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    Fun Friday for me
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    Happy Fun Friday to all.
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  • tom_mai78101 tom_mai78101:
    I found out you can't delete nor hide redirect links to existing threads. It will just stay there. I have no choice now but to start moving thread redirects to News Archive.
  • The Helper The Helper:
    That is not the way that it works for me I can delete redirects you just have to hit refresh sometimes big deletes will take a while as long as moves\
  • The Helper The Helper:
    You don't have to do that you can just leave stuff there in headline news for up to a year it was already down to like 8 months there is no rush.

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