Sci/Tech Tibetans inherited high-altitude gene from ancient human

tom_mai78101

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A “superathlete” gene that helps Sherpas and other Tibetans breathe easy at high altitudes was inherited from an ancient species of human. That’s the conclusion of a new study, which finds that the gene variant came from people known as Denisovans, who went extinct soon after they mated with the ancestors of Europeans and Asians about 40,000 years ago. This is the first time a version of a gene acquired from interbreeding with another type of human has been shown to help modern humans adapt to their environment.

Researchers have long wondered how Tibetans live and work at altitudes above 4000 meters, where the limited supply of oxygen makes most people sick. Other high-altitude people, such as Andean highlanders, have adapted to such thin air by adding more oxygen-carrying hemoglobin to their blood. But Tibetans have adapted by having less hemoglobin in their blood; scientists think this trait helps them avoid serious problems, such as clots and strokes caused when the blood thickens with more hemoglobin-laden red blood cells.

Researchers discovered in 2010 that Tibetans have several genes that help them use smaller amounts of oxygen efficiently, allowing them to deliver enough of it to their limbs while exercising at high altitude. Most notable is a version of a gene called EPAS1, which regulates the body’s production of hemoglobin. They were surprised, however, by how rapidly the variant of EPAS1 spread—initially, they thought it spread in 3000 years through 40% of high-altitude Tibetans, which is the fastest genetic sweep ever observed in humans—and they wondered where it came from.

Read more here. (Science)
 
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    I think imma give four or five weeks of notice today to my boss, and see how much that backfires on me. I know he's struggling to hire anyone though, so it's like, do a couple weeks of interviews with me and then we'll have two or three weeks to train someone to take over for me. Hopefully he doesn't fucking let me go in like two weeks cuz that would really fuck me up right now
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    Wouldn't it be better if you give 3 to 4 weeks of notice? So that, at least you are guaranteed for 1 more week of paycheck to hold you over?
  • tom_mai78101 tom_mai78101:
    By the way, where are you moving to?
  • Varine Varine:
    Back to Idaho for the summer, then maybe Houston in August or so, my girlfriend or whatever we are loved it there
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    I'm not sure yet, but my parents need some help cuz they're getting older and my mom has MS so can't do much anymore, so I'll be able to get their property fixed up so they can sell their other house. And the resort is stoked to have me back for the summer, cuz they always struggle with staff.
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    I think it'll be alright, even if they cut me loose a bit early I do have some money and I know plenty of people that will lend me the few hundred bucks to get up there. I'm just catching up after last year still, if I have to kite some bills for a couple weeks it'll be fine.
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    I hate my job but I do like one of my bosses, he does try really hard to get me what I need, and I want to make sure I leave with them comfortable with a new manager
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    I like my coworkers for the most part too as much as I bitch about them, they just aren't reliable. As kids tend to be, I was a shithead at 19 and 20 too I'm sure, so
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    Good luck on getting things going.
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    Eh, it'll be fine, I got it mostly planned out already. Roommates know, boss will know in about an hour when I go to work, I'll have a plane booked once we decide my last day, and I have a place to stay up there lined up for two or three months
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    That all came together surprisingly easily
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    I think I'm going to give 4 weeks, so that'll give me 2 more full checks probably, and then one more coming after I leave.
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    All that shit came together really well suprisingly. My boss was upset cuz I am really good at my job suprisingly, but he's stoked that he got 4 weeks, plus one or two if he needs it, my flight's book in mid June, but I start my new job almost immediately so it'll be nice to have some time to chill and pack and get my rooms cleaned out. He actually gave me a dollar raise right after I gave notice to thank me for not being short or just leaving and making sure I can help interview and train someone to replace me. He is really cool, his food truck has just been a nightmare to run. I get my vaccine next week finally, allegedly Idaho will let me have my license back when I get there, and I have all my bills up to date so it should be an easy move this time around.
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    sounds great :) have fun in Idaho
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    freaking Idaho
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    Yeah it sucks up there, but it'll be a bit easier for the summer probably.
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    When you get to Houston you will have your pick there is a huge shortage of good people to work in your field here. They are hiring everywhere and Texas is pretty much fully open.
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    for anyone else following this yes I am in Houston so Varine and I will RL meet gotta love it! Looking forward to it!
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    awesome
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    I think I'll be back down here around August or September, probably, if not a bit sooner. I took my old job back for the summer, so it'll be a lot easier to save up a bit and have a bit of money to actually get situated again
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