Sci/Tech Innovative Saliva-Based Glucose Sensor to Revolutionize Diabetes Monitoring

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A prototype sensor that measures glucose levels in saliva could eventually offer a simple, rapid, and painless way for people to monitor their diabetes, according to the King Abdullah University of Science & Technology (KAUST) researchers behind the technology.

Diabetes is a disease that occurs when the body cannot regulate its blood glucose levels. Raised glucose levels can lead to cardiovascular disease and other conditions, so it is vital that people with diabetes maintain their blood glucose at moderate levels.

People with diabetes have traditionally monitored their blood glucose using devices that analyze a drop of blood by pricking a finger several times a day. More recently, implanted sensors can provide continuous glucose monitoring without unpleasant pinpricks, but these devices can be less accurate for lower glucose levels and are not approved for children.

A more convenient way to monitor glucose could be through testing saliva, which is correlated to blood glucose levels. However, glucose concentrations are much lower in saliva than in blood, which has made it difficult to measure accurately without sophisticated laboratory equipment.

The KAUST team has now created a highly sensitive glucose detector based on a thin-film transistor. These small, lightweight, and low-power devices could be suitable for mass production as inexpensive disposable sensors, says team member Abhinav Sharma. “An easy-to-use noninvasive glucose-measuring device using saliva as a medium could be life-changing for millions of patients worldwide,” he says.

 
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