Prometheus
Everything is mutable; nothing is sacred
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Although public health efforts have eradicated some diseases and helped limit the impact of many others, malaria continues to present a massive public health issue. A large fraction of the world’s population lives in areas where the parasite poses a risk, and it kills a million people annually, most of them in the developing world.
The malarial parasite, Plasmodium, has proven tough to tackle for a variety of reasons. Once in a human, it manages to change the proteins that cover its surface often enough that our immune systems have trouble mounting a successful response. Unlike a bacteria or virus, the parasite is a eukaryote, just like humans, which means that it’s harder to find unique biochemical properties that would let us target it with drugs. Plasmodium has also been able to evolve resistance to the few drugs that we’ve been using to treat it. That evolution of resistance extends to its vectors, a few species of mosquitoes, which have also evolved resistance to many of the pesticides we have used to keep them in check.
All of that might seem to be enough to make tackling malaria seem like an intractable problem. But some researchers are reporting some success with a new approach to limiting its spread: engineering a mosquito parasite to attack it before it can reach humans.
More
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If this had been around earlier, I might not of gotten malaria!
The malarial parasite, Plasmodium, has proven tough to tackle for a variety of reasons. Once in a human, it manages to change the proteins that cover its surface often enough that our immune systems have trouble mounting a successful response. Unlike a bacteria or virus, the parasite is a eukaryote, just like humans, which means that it’s harder to find unique biochemical properties that would let us target it with drugs. Plasmodium has also been able to evolve resistance to the few drugs that we’ve been using to treat it. That evolution of resistance extends to its vectors, a few species of mosquitoes, which have also evolved resistance to many of the pesticides we have used to keep them in check.
All of that might seem to be enough to make tackling malaria seem like an intractable problem. But some researchers are reporting some success with a new approach to limiting its spread: engineering a mosquito parasite to attack it before it can reach humans.
More
---------------------------------------------------------------------
If this had been around earlier, I might not of gotten malaria!
