Health Embryonic pathway delivers stem cell traits

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Studies of how cancer cells spread have led to a surprising discovery about the creation of cells with adult stem-cell characteristics, offering potentially major implications for regenerative medicine and for cancer treatment.

Some cancer cells acquire the ability to migrate through the body by re-activating biological programs that have lain dormant since the embryo stage, as the lab of Robert Weinberg, a member of the MIT-affiliated Whitehead Institute for Biomedical Research, has helped to demonstrate in recent years. Now scientists in the Weinberg lab have shown that both normal and cancer cells that are induced to follow one of these pathways may gain properties of adult stem cells, including the ability to self-renew.

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