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It conflicts with concerns of repeat boosters, but authors warn against hypervaccination.
A 62-year-old man in Germany decided to get 217 COVID-19 vaccinations over the course of 29 months —for "private reasons." But, somewhat surprisingly, he doesn't seem to have suffered any ill effects from the excessive immunization, particularly weaker immune responses, according to a newly published case study in The Lancet Infectious Diseases.
The case is just one person, of course, so the findings can't be extrapolated to the general population. But, they conflict with a widely held concern among researchers that such overexposure to vaccination could lead to weaker immune responses. Some experts have raised this concern in discussions over how frequently people should get COVID-19 booster doses.
In cases of chronic exposure to a disease-causing germ, "there is an indication that certain types of immune cells, known as T-cells, then become fatigued, leading to them releasing fewer pro-inflammatory messenger substances," according to co-lead study author Kilian Schober from the Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene. This, along with other effects, can lead to "immune tolerance" that leads to weaker responses that are less effective at fighting off a pathogen, Schober explained in a news release.
The German man's extreme history of hypervaccination seemed like a good case to look for evidence of such tolerance and weaker responses. Schober and his colleagues learned of the man's case through news headlines—officials had opened a fraud investigation against the man, confirming 130 vaccinations over nine months, but no criminal charges were ever filed. "We then contacted him and invited him to undergo various tests in Erlangen [a city in Bavaria]," Schober said. "He was very interested in doing so." The man then reported an additional 87 vaccinations to the researchers, which in total included eight different vaccine formulations, including updated boosters.
arstechnica.com
A 62-year-old man in Germany decided to get 217 COVID-19 vaccinations over the course of 29 months —for "private reasons." But, somewhat surprisingly, he doesn't seem to have suffered any ill effects from the excessive immunization, particularly weaker immune responses, according to a newly published case study in The Lancet Infectious Diseases.
The case is just one person, of course, so the findings can't be extrapolated to the general population. But, they conflict with a widely held concern among researchers that such overexposure to vaccination could lead to weaker immune responses. Some experts have raised this concern in discussions over how frequently people should get COVID-19 booster doses.
In cases of chronic exposure to a disease-causing germ, "there is an indication that certain types of immune cells, known as T-cells, then become fatigued, leading to them releasing fewer pro-inflammatory messenger substances," according to co-lead study author Kilian Schober from the Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene. This, along with other effects, can lead to "immune tolerance" that leads to weaker responses that are less effective at fighting off a pathogen, Schober explained in a news release.
The German man's extreme history of hypervaccination seemed like a good case to look for evidence of such tolerance and weaker responses. Schober and his colleagues learned of the man's case through news headlines—officials had opened a fraud investigation against the man, confirming 130 vaccinations over nine months, but no criminal charges were ever filed. "We then contacted him and invited him to undergo various tests in Erlangen [a city in Bavaria]," Schober said. "He was very interested in doing so." The man then reported an additional 87 vaccinations to the researchers, which in total included eight different vaccine formulations, including updated boosters.
German man got 217 COVID shots over 29 months—here’s how it went
It conflicts with concerns of repeat boosters, but authors warn against hypervaccination.
